Ben Stiller may replace Justin Theroux as director on Zoolander 2.
Theroux - who wrote the script for the long-awaited comedy sequel - has said that other commitments may force him out of the director's chair.
"We've got a script for the sequel, and we've just been in talks again," he told Vulture.
"We're trying to sharpen it and hone it and, actually, I don't want to jinx anything, but it looks like it actually might be starting to get up and running."
Theroux said that he will not be able to direct Zoolander 2 if his show The Leftovers returns for a second season at HBO.
"I don't think I'm going to do it anymore. It really depends on whether the show gets picked up," he continued. "If it gets picked up, then I don't think I'll have the time to do it. So it'll probably get handed to Ben, which would be awesome."
In June, Stiller said that production on the sequel to 2011's Zoolander would not begin "any time soon".